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We examined the effects of a 10–14-weeks inpatient lifestyle modification program, including minimum 90 min of physical activity (PA) five days/week, on body composition, CVD risk factors, and eating behavior in 139 obese subjects (BMI 42.6 ± 5.2 kg/m 2 ). Completion rate was 71% ( n  = 71) in the intensive lifestyle intervention (ILI) group and 85% ( n  = 33) among waiting list controls. Compared to controls body weight (−17.0 (95% CI: −18.7, −15.3) kg,  P  < 0.0001), fat mass (−15.2 (95% CI: −17.4, −13.1) kg,  P  < 0.0001), fat free mass (−1.2 (95% CI: −2.2, −0.2) kg,  P  = 0.016) and visceral fat (−86.6(95% CI: −97.4, −75.7) cm 2 ,  P  < 0.0001) were reduced in the ILI-group after 10–14 weeks. Within the ILI-group weight loss was −23.8 (95% CI: −25.9, −21.7) kg,  P  < 0.0001 and -20.3 (95% CI: −23.3, −17.3) kg,  P  < 0.0001, after six and 12 months, respectively. Systolic BP, glucose, triglycerides, and LDL-C were reduced, and HDL-C was increased (all  P  ≤ 0.006) after 10–14 weeks within the ILI group. The reduction in glucose and increase in HDL-C were sustained after 12 months (all  P  < 0.0001). After one year, weight loss was related to increased cognitive restraint and decreased uncontrolled eating (all  P  < 0.05). Thus, ILI including high volume of PA resulted in weight loss with almost maintenance of fat-free mass, favorable changes in CVD risk factors, and eating behavior in subjects with severe obesity.

journal of obesity

Changes in Body Composition, Cardiovascular Disease Risk Factors, and Eating Behavior after an Intensive Lifestyle Intervention with High Volume of Physical Activity in Severely Obese Subjects: A Prospective Clinical Controlled Trial