Molecular Classification of Hepatocellular Adenomas | Zendy

JeanCharles Nault | Zendy; Jessica ZucmanRossi | Zendy

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Molecular Classification of Hepatocellular Adenomas

Author(s) -

JeanCharles Nault,

Jessica ZucmanRossi

Publication year - 2013

Publication title -

international journal of hepatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.734

H-Index - 14

eISSN - 2090-3448

pISSN - 2090-3456

DOI - 10.1155/2013/315947

Subject(s) - medicine , hepatocellular carcinoma , wnt signaling pathway , malignant transformation , gnas complex locus , pathological , hepatocyte nuclear factors , hepatocellular adenoma , transcription factor , stat3 , hnf1a , cancer research , somatic cell , bioinformatics , pathology , signal transduction , endocrinology , genetics , gene , biology , diabetes mellitus

Hepatocellular adenomas (HCAs) are benign tumors developed in normal liver most frequently in women before menopause. HCAs lead to diagnostic pitfalls and several difficulties to assess the risk of malignant transformation in these young patients. Recent advances in basic knowledge have revealed a molecular classification related to risk factors, pathological features, and risk of transformation in hepatocellular carcinoma. Three major molecular pathways have been identified altered in specific HCA subgroups that are defined by either (1) inactivation of hepatocyte nuclear factor 1A ( HNF1A ) transcription factor, (2) activation of the WNT/ β -catenin by CTNNB1 mutations, or (3) activation of the IL6/STAT3 pathway by somatic mutation of IL6ST , GNAS , or STAT3 . Here, we will review the different molecular classes of HCA.

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