Selective Intermittent Preventive Treatment of Vivax Malaria: Reduction of Malaria Incidence in an Open Cohort Study in Brazilian Amazon | Zendy

Tony Hiroshi Katsuragawa | Zendy; Luiz Herman Soares Gil | Zendy; Alzemar Alves de Lima | Zendy; Elci Marlei Freitag | Zendy; Tatiana Marcondes dos Santos | Zendy; Maria Teixeira do Nascimento Filha | Zendy; Alcides Procópio Justiniano dos Santos Júnior | Zendy; Josiane Mendes da Silva | Zendy; Aline de Freitas Rodrigues | Zendy; Mauro Shugiro Tada | Zendy; Cor Jésus Fernandes Fontes | Zendy; Luiz Hildebrando Pereira da Silva | Zendy

Open Access

Selective Intermittent Preventive Treatment of Vivax Malaria: Reduction of Malaria Incidence in an Open Cohort Study in Brazilian Amazon

Author(s) -

Tony Hiroshi Katsuragawa,

Luiz Herman Soares Gil,

Alzemar Alves de Lima,

Elci Marlei Freitag,

Tatiana Marcondes dos Santos,

Maria Teixeira do Nascimento Filha,

Alcides Procópio Justiniano dos Santos Júnior,

Josiane Mendes da Silva,

Aline de Freitas Rodrigues,

Mauro Shugiro Tada,

Cor Jésus Fernandes Fontes,

Luiz Hildebrando Pereira da Silva

Publication year - 2013

Publication title -

malaria research and treatment

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.726

H-Index - 15

eISSN - 2090-8075

pISSN - 2044-4362

DOI - 10.1155/2013/310246

Subject(s) - malaria , vivax malaria , incidence (geometry) , medicine , chloroquine , plasmodium vivax , environmental health , transmission (telecommunications) , christian ministry , cohort , tropical medicine , pediatrics , immunology , plasmodium falciparum , philosophy , physics , electrical engineering , theology , pathology , engineering , optics

In children, the Intermittent Preventive Treatment (IPTc), currently called Seasonal Malaria Chemoprevention (SMC), was considered effective on malaria control due to the reduction of its incidence in Papua New Guinea and in some areas with seasonal malaria in Africa. However, the IPT has not been indicated because of its association with drug resistance and for hindering natural immunity development. Thus, we evaluated the alternative IPT impact on malaria incidence in three riverside communities on Madeira River, in the municipality of Porto Velho, RO. We denominate this scheme Selective Intermittent Preventive Treatment (SIPT). The SIPT consists in a weekly dose of two 150 mg chloroquine tablets for 12 weeks, for adults, and an equivalent dose for children, after complete supervised treatment for P. vivax infection. This scheme is recommend by Brazilian Health Ministry to avoid frequent relapses. The clinic parasitological and epidemiological surveillance showed a significant reduction on vivax malaria incidence. The results showed a reduction on relapses and recurrence of malaria after SIPT implementation. The SIPT can be effective on vivax malaria control in localities with high transmission risk in the Brazilian Amazon.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research