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This study explores the therapeutic effects of Xiangshao granules in a mouse depression model and examines the potential molecular mechanisms involved. After 21 consecutive days of chronic stress challenge, all mice were divided into three groups: control group, depression group, and Xiangshao granule treatment group. On the 22nd day, rats in the Xiangshao granule treatment group received Xiangshao granules via gastrogavage for 3 consecutive weeks. Depression group mice showed a significant reduction of crossings ( P  < 0.01) but not rearings ( P  < 0.05). Serum CRH, CORT, and ACTH levels were significantly increased in depression mice compared with control ( P  < 0.05) and the expression levels of hippocampal BDNF and TrkB were reduced in the model group ( P  < 0.05). However, Xiangshao granule treatment remarkably rescued the decrease in the body weight ( P  < 0.05), increased crossings in the open field test ( P  < 0.05), upregulated the expression of hippocampal BDNF and TrkB expression, and reduced the serum CRH, CORT, and ACTH concentrations compared with the depression group ( P  < 0.05). Collectively, these results demonstrated that Xiangshao granule could effectively induce antidepressive effects in the depression mouse model by ameliorating the expression of hippocampal BDNF and TrkB.

Xiangshao Granule Exerts Antidepressive Effects in a Depression Mouse Model by Ameliorating Deficits in Hippocampal BDNF and TrkB