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Ultrahigh-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry (UPLC-QTOF/MS) was developed for rapid and sensitive analysis of the effect of rice wine on the metabolites of the main components of herbal medicine in rat urine. Using  Cornus officinalis  as a model of herbal medicine, the metabolite profiles of crude and processed (steaming the crude drug presteeped in rice wine)  Cornus officinalis  extracts in rat urine were investigated. The metabolites of  Cornus officinalis  were identified by using dynamic adjustment of the fragmentor voltage to produce structure-relevant fragment ions. In this work, we identified the parent compounds and metabolites of crude and processed  Cornus officinalis  in rats. In total, three parent compounds and seventeen new metabolites of  Cornus officinalis  were found in rats. The contents of the parent compounds and metabolites  in vivo  varied significantly after intragastric (i.g.) administration of aqueous extracts of crude and processed  Cornus officinalis . Data from this study suggests that UPLC-QTOF/MS could be used as a potential tool for uncovering the effects of excipients found in the metabolites of the main components of herbal medicine,  in vivo , to predict and discover the processing mechanisms of herbal medicine.

evidence-based complementary and alternative medicine

Investigation of the Effect of Rice Wine on the Metabolites of the Main Components of Herbal Medicine in Rat Urine by Ultrahigh-Performance Liquid Chromatography-Quadrupole/Time-of-Flight Mass Spectrometry: A Case Study on<i>Cornus officinalis</i>

Investigation of the Effect of Rice Wine on the Metabolites of the Main Components of Herbal Medicine in Rat Urine by Ultrahigh-Performance Liquid Chromatography-Quadrupole/Time-of-Flight Mass Spectrometry: A Case Study onCornus officinalis