Therapeutic Potential of Andrographolide Isolated from the Leaves ofAndrographis paniculataNees for Treating Lung Adenocarcinomas | Zendy

YuTang Tung | Zendy; HsiaoLing Chen | Zendy; Hsin-Chung Tsai | Zendy; ShangHsun Yang | Zendy; Yi-Chun Chang | Zendy; ChuanMu Chen | Zendy

Open Access

Therapeutic Potential of Andrographolide Isolated from the Leaves ofAndrographis paniculataNees for Treating Lung Adenocarcinomas

Author(s) -

YuTang Tung,

HsiaoLing Chen,

Hsin-Chung Tsai,

ShangHsun Yang,

Yi-Chun Chang,

ChuanMu Chen

Publication year - 2013

Publication title -

evidence-based complementary and alternative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.552

H-Index - 90

eISSN - 1741-4288

pISSN - 1741-427X

DOI - 10.1155/2013/305898

Subject(s) - andrographolide , andrographis paniculata , medicine , pharmacology , pathology , alternative medicine

Andrographolide is one of the major diterpene lactones found in Andrographis paniculata Nees and exhibits remarkable inhibitory effects on various cancers. In this study, the antipulmonary cancer effects of andrographolide were studied in a lung tumor mouse model induced by human vascular endothelial growth factor A 165 ( hVEGF -A 165 ). These results demonstrated that andrographolide significantly reduced the expression of hVEGF-A 165 compared with a mock group in the Clara cells of the lungs. In addition, andrographolide also decreased tumor formation by reducing VEGF, EGFR, Cyclin A, and Cyclin B expression on the transcriptional and translational levels. These results indicated that andrographolide treatment on the overexpression of VEGF can arrest the cell cycle, which induced pulmonary tumors in transgenic mice. In conclusion, the antiangiogenesis and chemotherapeutic potential of andrographolide may provide a cure for pulmonary tumors in the future.

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