Assessing the Impact of Drug Resistance on the Transmission Dynamics of Typhoid Fever | Zendy

Steady Mushayabasa | Zendy; C. P. Bhunu | Zendy; E. T. Ngarakana-Gwasira | Zendy

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Assessing the Impact of Drug Resistance on the Transmission Dynamics of Typhoid Fever

Author(s) -

Steady Mushayabasa,

C. P. Bhunu,

E. T. Ngarakana-Gwasira

Publication year - 2013

Publication title -

computational biology journal

Language(s) - English

Resource type - Journals

eISSN - 2314-4173

pISSN - 2314-4165

DOI - 10.1155/2013/303645

Subject(s) - typhoid fever , drug , drug resistance , transmission (telecommunications) , outbreak , medicine , enteric fever , intensive care medicine , virology , biology , pharmacology , microbiology and biotechnology , computer science , telecommunications

Typhoid fever continues to be a major public health problem in the developing world. Antibiotic therapy has been the main stay of treating typhoid fever for decades. The emergence of drug-resistant typhoid strain in the last two decades has been a major problem in tackling this scourge. A mathematical model for investigating the impact of drug resistance on the transmission dynamics of typhoid fever is developed. The reproductive number for the model has been computed. Numerical results in this study suggest that when a typhoid outbreak occurs with more drug-sensitive cases than drug-resistant cases, then it may take 10–15 months for symptomatic drug-resistant cases to outnumber all typhoid cases, and it may take an average of 15–20 months for nonsymptomatic drug-resistant cases to outnumber all drug-sensitive cases

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