Open AccessA Convenient Synthesis of C‐3‐Aryloxymethyl Imidazo[1,2‐a]Pyridine Derivatives
Author(s) -
Sridevi Kona,
Rama Suresh Ravi,
Venkata N. R. Chava,
P. Sridhar
Publication year - 2012
Publication title -
journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.436
H-Index - 50
eISSN - 2090-9063
pISSN - 2090-9071
DOI - 10.1155/2013/296792
Subject(s) - chemistry , pyridine , moiety , ether , aryl , carbene , medicinal chemistry , stereochemistry , organic chemistry , catalysis , alkyl
Imidazo[1,2-a]pyridine-based tosylhydrazone was prepared and treated with K2CO3 in dioxane at 110°C to generate the corresponding carbene in situ. It was coupled with a variety of aryl alcohols in one pot to obtain a series of imidazo[1,2-a]pyridine derivatives possessing aryl ether moiety at C-3 position
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