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Cytokines play an essential role during active tuberculosis disease and cytokine genes have been described in association with altered cytokine levels. Therefore, the aim of this study was to verify if  IFNG, IL12B, TNF, IL17A, IL10, and TGFB1  gene polymorphisms influence the immune response of Brazilian patients with pulmonary tuberculosis (PTB) at different time points of antituberculosis treatment (T1, T2, and T3). Our results showed the following associations:  IFNG  +874 T allele and  IFNG  +2109 A allele with higher IFN-  γ   levels;  IL12B  +1188 C allele with higher IL-12 levels;  TNF  −308 A allele with higher TNF-  α   plasma levels in controls and mRNA levels in PTB patients at T1;  IL17A  A allele at rs7747909 with higher IL-17 levels;  IL10  −819 T allele with higher IL-10 levels; and  TGFB1  +29 CC genotype higher TGF-  β   plasma levels in PTB patients at T2. The present study suggests that  IFNG  +874T/A,  IFNG  +2109A/G,  IL12B  +1188A/C,  IL10  −819C/T, and  TGFB1  +21C/T are associated with differential cytokine levels in pulmonary tuberculosis patients and may play a role in the initiation and maintenance of acquired cellular immunity to tuberculosis and in the outcome of the active disease while on antituberculosis treatment.

Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment