A Novel Porous Gelatin Composite Containing Naringin for Bone Repair | Zendy

KuoYu Chen | Zendy; KuenCherng Lin | Zendy; Yueh-Sheng Chen | Zendy; ChunHsu Yao | Zendy

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A Novel Porous Gelatin Composite Containing Naringin for Bone Repair

Author(s) -

KuoYu Chen,

KuenCherng Lin,

Yueh-Sheng Chen,

ChunHsu Yao

Publication year - 2013

Publication title -

evidence-based complementary and alternative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.552

H-Index - 90

eISSN - 1741-4288

pISSN - 1741-427X

DOI - 10.1155/2013/283941

Subject(s) - naringin , genipin , gelatin , alkaline phosphatase , chemistry , composite number , biocompatibility , acid phosphatase , nuclear chemistry , materials science , biomedical engineering , chromatography , biochemistry , enzyme , composite material , medicine , organic chemistry , chitosan

As Gu-Sui-Bu (GSB) is a commonly used Chinese medical herb for therapeutic treatment of bone-related diseases, naringin is its main active component. This study elucidates how various concentrations of naringin solution affect the activities of bone cells, based on colorimetric, alkaline phosphatase activity, nodule formation, and tartrate-resistant acid phosphatase activity assays to determine the optimal concentration of naringin. GGT composite was obtained by combining genipin cross-linked gelatin and β -tricalcium phosphate. GGTN composite was prepared by mixing GGT composite with the predetermined concentration of naringin. Porous GGT and GGTN composites were then made using a salt-leaching procedure. The potential of the composites in repairing bone defects was evaluated and compared in vivo by using the biological response of rabbit calvarial bone to these composites. Consequently, the most effective concentration of naringin was 10 mg/mL, which significantly enhanced the proliferation of osteoblasts, osteoclast activity, and nodule formation without affecting the alkaline phosphatase activity of osteoblasts and mitochondrial activity of mixed-bone cells. Radiographic analysis revealed greater new bone ingrowth in the GGTN composite than in the GGT composite at the same implantation time. Therefore, the GGTN composite is highly promising for use as a bone graft material.

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