Synthesis and Antifungal Studies of (2E)‐N‐Benzyl‐N′‐phenylbut‐2‐enediamide and (2E)‐N,N′‐Dibenzylbut‐2‐enediamide Analogues | Zendy

Habila J. Dama | Zendy; Kandappa H. Reddy | Zendy; Patrick Govender | Zendy; Neil A. Koorbanally | Zendy

Open Access

Synthesis and Antifungal Studies of (2E)‐N‐Benzyl‐N′‐phenylbut‐2‐enediamide and (2E)‐N,N′‐Dibenzylbut‐2‐enediamide Analogues

Author(s) -

Habila J. Dama,

Kandappa H. Reddy,

Patrick Govender,

Neil A. Koorbanally

Publication year - 2013

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.436

H-Index - 50

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2013/281341

Subject(s) - chemistry , broth microdilution , stereochemistry , candida krusei , yeast , antifungal , candida albicans , medicinal chemistry , corpus albicans , organic chemistry , minimum inhibitory concentration , microbiology and biotechnology , antimicrobial , biochemistry , biology

A series of eleven butanediamine analogues, of which nine were new, were synthesized by the nucleophilic substitution of aromatic amines and benzylamines with maleic anhydride and tested on four yeast strains of Candida species using the broth microdilution method. Compounds 3a and 3c with an unsubstituted phenyl ring and a 3-methoxyphenyl ring, respectively, are the most active against the fungal species with MIC values ranging from 20.2 to 80.6 μM for C. albicans and C. parapsilosis and 178.5 and 161.2 μM for C. krusei, respectively

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