Astragalus Polysaccharide Suppresses the Expression of Adhesion Molecules through the Regulation of the p38 MAPK Signaling Pathway in Human Cardiac Microvascular Endothelial Cells after Ischemia-Reperfusion Injury | Zendy

Haiyan Zhu | Zendy; Yonghong Gao | Zendy; Wang Zhi-Yao | Zendy; Bing Xu | Zendy; Aiming Wu | Zendy; Yanwei Xing | Zendy; Bei Liu | Zendy; Lixia Lou | Zendy; Lixin Chen | Zendy

Open Access

Astragalus Polysaccharide Suppresses the Expression of Adhesion Molecules through the Regulation of the p38 MAPK Signaling Pathway in Human Cardiac Microvascular Endothelial Cells after Ischemia-Reperfusion Injury

Author(s) -

Haiyan Zhu,

Yonghong Gao,

Wang Zhi-Yao,

Bing Xu,

Aiming Wu,

Yanwei Xing,

Bei Liu,

Lixia Lou,

Lixin Chen

Publication year - 2013

Publication title -

evidence-based complementary and alternative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.552

H-Index - 90

eISSN - 1741-4288

pISSN - 1741-427X

DOI - 10.1155/2013/280493

Subject(s) - astragalus , reperfusion injury , downregulation and upregulation , hypoxia (environmental) , mapk/erk pathway , ischemia , pharmacology , p38 mitogen activated protein kinases , cell adhesion molecule , signal transduction , inflammation , microbiology and biotechnology , medicine , traditional chinese medicine , chemistry , biology , immunology , biochemistry , pathology , alternative medicine , organic chemistry , oxygen , gene

Astragalus polysaccharide is a major component of radix astragali, a vital qi-reinforcing herb medicine with favorable immune-regulating effects. In a previous animal experiment, we demonstrated that astragalus polysaccharide effectively alleviates ischemia-reperfusion injury (IRI) of cardiac muscle through the regulation of the inflammatory reactions. However, the relationship between this herb and the cohesion molecules on the cell surface remains controversial. In this study, human cardiac microvascular endothelial cells (HCMECs) were used to validate the protective effects of astragalus under an IRI scheme simulated through hypoxia/reoxygenation in vitro. The results indicated that astragalus polysaccharide inhibited the cohesion between HCMECs and polymorphonuclear leukocyte (PMN) during IRI through the downregulation of p38 MAPK signaling and the reduction of cohesive molecule expression in HCMECs.

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