Antiulcer Activity of Indigenous PlantOperculina turpethumLinn. | Zendy

Vidya Ignatius | Zendy; Madhusudhanan Narayanan | Zendy; Venkataraman Subramanian | Zendy; Balasubramanian Maruthaiveeran Periyasamy | Zendy

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Antiulcer Activity of Indigenous PlantOperculina turpethumLinn.

Author(s) -

Vidya Ignatius,

Madhusudhanan Narayanan,

Venkataraman Subramanian,

Balasubramanian Maruthaiveeran Periyasamy

Publication year - 2013

Publication title -

evidence-based complementary and alternative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.552

H-Index - 90

eISSN - 1741-4288

pISSN - 1741-427X

DOI - 10.1155/2013/272134

Subject(s) - medicine , ranitidine , traditional medicine , peptic ulcer , bark (sound) , aspirin , pharmacology , biology , ecology

In the Indian traditional system of medicine Operculina turpethum is commonly used to treat various ailments including peptic ulcer, inflammation, and pain. Ulcer preventive and ulcer protective activities of HAOP and MOP stem bark extracts of Operculina turpethum (100 mg/kg, b.w., orally) were evaluated employing aspirin + pylorus ligation (APL) model in experimental rats. The results suggested that both extracts (HAOP and MOP) possess enhanced ulcer preventive and protective activities when compared with the standard drug ranitidine. HAOP showed more pronounced effect when compared to MOP. Further the result of the histopathological and biochemical studies also confirms potent ulcer preventive and protective nature of a extracts in a similar manner.

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