Open AccessGlobal Dynamics of HIV Infection of CD4+T Cells and Macrophages
Author(s) -
A. M. Ełaiw,
Ahuod Alsheri
Publication year - 2013
Publication title -
discrete dynamics in nature and society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.264
H-Index - 39
eISSN - 1607-887X
pISSN - 1026-0226
DOI - 10.1155/2013/264759
Subject(s) - invariant (physics) , virus , steady state (chemistry) , stability (learning theory) , dynamics (music) , human immunodeficiency virus (hiv) , stability theory , lyapunov function , mole , virology , biology , algorithm , physics , computer science , medicine , mathematical physics , chemistry , machine learning , quantum mechanics , acoustics , nonlinear system
We study the global dynamics of an HIV infection model describing the interaction of the HIV with CD4+ T cells and macrophages. The incidence rate of virus infection and the growth rate of the uninfected CD4+ T cells and macrophages are given by general functions. We have incorporated two types of distributed delays into the model to account for the time delay between the time the uninfected cells are contacted by the virus particle and the time for the emission of infectious (matures) virus particles. We have established a set of conditions which are sufficient for the global stability of the steady states of the model. Using Lyapunov functionals and LaSalle's invariant principle, we have proven that if the basic reproduction number R0 is less than or equal to unity, then the uninfected steady state is globally asymptotically stable (GAS), and if the infected steady state exists, then it is GAS
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