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The virulence factors of  Candida albicans  are germ tube and biofilm formation, adherence to host tissues, and production of hydrolytic enzymes. This study investigated the effect of  Dodonaea viscosa  var.   angustifolia  extract on the germ tube and biofilm formation of  C. albicans . Serum containing the three subinhibitory concentrations of leaf extract was inoculated with  C. albicans , incubated, and viewed under a light microscope. Number of cells with germ tube was recorded and the results were analysed using Scheffe test for pairwise comparison. Biofilms were grown on coverslips in the presence of plant extracts and processed for scanning electron microscopy (SEM). Planktonic cells were grown in the presence of plant extract for 6 h and processed for electron microscopy (TEM).  The crude plant extract significantly ( P  < 0.01) reduced the germ tube formation of  C. albicans  at 3.125 (85.36%), 1.56 (61.91%), and 0.78 mg/mL (26.27%) showing a concentration dependent effect. SEM results showed concentration dependent reduction in biofilm and hyphae formation. TEM results showed that the plant extract caused damage to the cell wall and cell membrane. DVA extract has ability to reduce virulence of  C. albicans  by inhibiting germ tube and biofilm formation through damage to the cell wall. Therefore, it has therapeutic potential.

Dodonaea viscosavar.angustifoliaInhibits Germ Tube and Biofilm Formation byC. albicans