Synthesis of N-(6-(4-(Piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome | Zendy

Nabajyoti Deka | Zendy; Swapnil Bajare | Zendy; Jessy Anthony | Zendy; Amrutha Nair | Zendy; Anagha Damre | Zendy; Dharmeshkumar Patel | Zendy; Chandrika BRao | Zendy; H. Sivaramakrishnan | Zendy; Shivaprakash Jagalur Mutt | Zendy; Chandan Wilankar | Zendy; Rosalind Marita | Zendy

Open Access

Synthesis of N-(6-(4-(Piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome

Author(s) -

Nabajyoti Deka,

Swapnil Bajare,

Jessy Anthony,

Amrutha Nair,

Anagha Damre,

Dharmeshkumar Patel,

Chandrika BRao,

H. Sivaramakrishnan,

Shivaprakash Jagalur Mutt,

Chandan Wilankar,

Rosalind Marita

Publication year - 2013

Publication title -

international journal of medicinal chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-2069

pISSN - 2090-2077

DOI - 10.1155/2013/201580

Subject(s) - insulin resistance , type 2 diabetes mellitus , metabolic syndrome , insulin , medicine , metabolic disorder , type 2 diabetes , endocrinology , diabetes mellitus , pharmacology

Metabolic syndrome is a widely prevalent multifactorial disorder associated with an increased risk of cardiovascular disease and type 2 diabetes mellitus. High plasma levels of insulin and glucose due to insulin resistance are a major component of the metabolic disorder. Thiazolidinediones (TZDs) are potent PPAR γ ligand and used as insulin sensitizers in the treatment of type 2 diabetes mellitus. They are potent insulin-sensitizing agents but due to adverse effects like hepatotoxicity, a safer alternative of TZDs is highly demanded. Here we report synthesis of N-(6-(4-(piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide derivatives as an alternate remedy for insulin resistance.

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