Programmed Cell Death Induced by Modulated Electrohyperthermia | Zendy

Nóra Meggyesházi | Zendy; Gábor Andócs | Zendy; Tibor Krenács | Zendy

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Programmed Cell Death Induced by Modulated Electrohyperthermia

Author(s) -

Nóra Meggyesházi,

Gábor Andócs,

Tibor Krenács

Publication year - 2013

Publication title -

conference papers in medicine

Language(s) - English

Resource type - Journals

eISSN - 2314-5862

pISSN - 2314-534X

DOI - 10.1155/2013/187835

Subject(s) - tunel assay , apoptosis , immunohistochemistry , programmed cell death , colorectal cancer , downregulation and upregulation , cancer research , cell culture , pathology , medicine , cancer , biology , biochemistry , genetics , gene

Background. Modulated electrohyperthermia (mEHT) is a noninvasive technique for targeted tumor treatment. Method. HT29 human colorectal carcinoma cell line xenografted to both femoral regions of BalbC/nu/nu mice was treated with a single shot OTM treatment. Histomorphologic, immunohistochemical analysis TUNEL assay, and R&D Apoptosis array were performed on tissue samples. Results. mEHT caused a selective tumor demolition. An upregulation of TRAIL-R2 and FAS was observed. Cleaved caspase-3 positive cells appear at the tumor periphery. Cytochrome c and AIF release was observed in line with massive TUNEL positivity. Conclusion. In HT29 colorectal cancer xenograft, mEHT caused massive caspase independent cell death.

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