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Objective . To evaluate what types of DNA damages are detected in rheumatoid arthritis (RA).  Methods . The DNA adducts such as 8-oxo-hydroxy-7,8-dihydro-2′-deoxyguanosine (8-oxo-dG), 1,N 6 -etheno-2′-deoxyadenosine (  ε  dA), and heptanone-etheno-2′-deoxycytidine (H  ε  dC) in genomic DNAs, derived from whole blood cells from 46 RA patients and 31 healthy controls, were analyzed by high-performance liquid chromatography tandem mass spectrometry, and their levels in RA patients and controls were compared. In addition, correlation between DNA adducts and clinical parameters of RA was analyzed.  Results . Compared with controls, the levels of H  ε  dC in RA were significantly higher ( P  < 0.0001) and age dependent ( r  = 0.43,  P  < 0.01), while there was no significant difference in 8-oxo-dG and   ε  dA accumulation between RA patients and controls. H  ε  dC levels correlated well with the number of swollen joints ( r  = 0.57,  P  < 0.0001) and weakly with the number of tender joints ( r  = 0.26,  P  = 0.08) of RA patients, while they did not show a significant association with serological markers such as C-reactive protein and matrix metalloproteinase 3.  Conclusion . These findings indicate that H  ε  dC may have some influence on the development of RA and/or its complications.

DNA Damage in Rheumatoid Arthritis: An Age-Dependent Increase in the Lipid Peroxidation-Derived DNA Adduct, Heptanone-Etheno-2′-Deoxycytidine