Synthesis and Antimicrobial Evaluation of a New Series ofN-1,3-Benzothiazol-2-ylbenzamides | Zendy

Domenico Armenise | Zendy; Alessia Carocci | Zendy; Alessia Catalano | Zendy; Marilena Muraglia | Zendy; Ivana Defrenza | Zendy; Nicolino De Laurentis | Zendy; Antonio Rosato | Zendy; Filomena Faustina Rina Corbo | Zendy; Carlo Franchini | Zendy

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Synthesis and Antimicrobial Evaluation of a New Series ofN-1,3-Benzothiazol-2-ylbenzamides

Author(s) -

Domenico Armenise,

Alessia Carocci,

Alessia Catalano,

Marilena Muraglia,

Ivana Defrenza,

Nicolino De Laurentis,

Antonio Rosato,

Filomena Faustina Rina Corbo,

Carlo Franchini

Publication year - 2013

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.436

H-Index - 50

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2013/181758

Subject(s) - enterococcus faecalis , antimicrobial , antibiotics , microbiology and biotechnology , chemistry , pathogen , escherichia coli , biology , biochemistry , gene

Enterococcus faecalis is a Gram-positive commensal inhabitant of the intestinal tract of humans, animals, and insects. However, it is also an opportunistic pathogen and has emerged as a leading cause of hospital-acquired extraintestinal infections. Fluoroquinolones have been frequently used to treat E. faecalis infections, and the emergence of fluoroquinolone-resistant E. faecalis strains has recently been reported in several countries. Thus, the identifications of new antibiotics specifically directed to E. faecalis may be envisaged. In this paper, a new series of N-1,3-benzothiazol-2-ylbenzamides have been designed, synthesized, and evaluated for their in vitro antimicrobial activities. Among the tested compounds, 3i was active against E. faecalis

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