An Efficient One‐Pot Multicomponent Synthesis of 4‐Aza‐Podophyllotoxin Derivatives in Ionic Liquid | Zendy

Hossein Naeimi | Zendy; Zahra Rashid | Zendy; AmirHassan Zarnani | Zendy; Ramin Ghahremanzadeh | Zendy

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An Efficient One‐Pot Multicomponent Synthesis of 4‐Aza‐Podophyllotoxin Derivatives in Ionic Liquid

Author(s) -

Hossein Naeimi,

Zahra Rashid,

AmirHassan Zarnani,

Ramin Ghahremanzadeh

Publication year - 2013

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.436

H-Index - 50

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2013/169695

Subject(s) - chemistry , ionic liquid , catalysis , trifluoromethanesulfonate , podophyllotoxin , organic chemistry , alum , combinatorial chemistry , reaction conditions

A simple, green, and efficient procedure for the synthesis of 4-aza-podophyllotoxin derivatives by using a one-pot three-component reaction of benzaldehydes, 1,3-cyclohexanediones, and anilinolactones in the presence of catalytic amount of alum in 1-butyl-3-methylimidazolium triflate as green media is described. This reaction proceeded under mild conditions with the use of an inexpensive and readily available catalyst, high to excellent yields, and simple workup procedure

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