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We isolated a single chemical compound from  A. continentalis  and identified it to be kaurenoic acid (KA) and investigated the influence of anticariogenic properties. Inhibitory effects of KA on cariogenic properties such as growth, acid production, biofilm formation, and the adherence of  S. mutans  were evaluated. Furthermore, real-time PCR analysis was performed to evaluate the influence of KA on the genetic expression of virulence factors. KA significantly inhibited the growth and acid production of  S. mutans  at 2–4   μ  g/mL and 4   μ  g/mL of KA, respectively. Furthermore, the adherence onto S-HAs was inhibited at 3-4   μ  g/mL of KA and biofilm formation was significantly inhibited when treated with 3   μ  g/mL KA and completely inhibited at 4   μ  g/mL. Also, the inhibitory effect of KA on biofilm formation was confirmed by SEM. In confocal laser scanning microscopy, bacterial viability gradually decreased by KA in a dose dependent manner. Real-time PCR analysis showed that the expressions of  gtfB, gtfC, gbpB, spaP, brpA, relA , and  vicR  were significantly decreased in  S. mutans  when it was treated with KA. These results suggest that KA from  A. continentalis  may be a useful agent for inhibiting the cariogenic properties of  S. mutans .

Kaurenoic Acid fromAralia continentalisInhibits Biofilm Formation ofStreptococcus mutans