Synthesis and Antibacterial, Antimycobacterial Activity of 7-[4-{5-(2-Oxo-2-p-substituted-phenylethylthio)-1,3,4-thiadiazol-2yl}-3′-methylpiperazinyl] Quinolone Derivatives | Zendy

Kapil Agrawal | Zendy; Gokul S. Talele | Zendy

Open Access

Synthesis and Antibacterial, Antimycobacterial Activity of 7-[4-{5-(2-Oxo-2-p-substituted-phenylethylthio)-1,3,4-thiadiazol-2yl}-3′-methylpiperazinyl] Quinolone Derivatives

Author(s) -

Kapil Agrawal,

Gokul S. Talele

Publication year - 2012

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.436

H-Index - 50

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2013/147565

Subject(s) - chemistry , antimycobacterial , quinolone , combinatorial chemistry , antibacterial activity , medicinal chemistry , stereochemistry , antibiotics , mycobacterium tuberculosis , bacteria , tuberculosis , biochemistry , medicine , pathology , biology , genetics

Currently we screened 9 newer synthesized fluoroquinolone derivatives 5(a–i) against two gram positive, two gram negative bacterial strains, and mycobacterium tuberculosis H37Rv. These analogues were confirmed by IR, 1H NMR, 13C NMR, and elemental analysis. Selected compounds were confirmed by mass spectral study. Compounds 5(b–d) showed comparable biological activities and other analogues of the series showed moderate-to-weak activity, as compared to the reference marketed drugs

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