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Currently we screened 9 newer synthesized fluoroquinolone derivatives 5(a–i) against two gram positive, two gram negative bacterial strains, and mycobacterium tuberculosis H37Rv. These analogues were confirmed by IR, 1H NMR, 13C NMR, and elemental analysis. Selected compounds were confirmed by mass spectral study. Compounds 5(b–d) showed comparable biological activities and other analogues of the series showed moderate-to-weak activity, as compared to the reference marketed drugs

journal of chemistry

Synthesis and Antibacterial, Antimycobacterial Activity of 7-[4-{5-(2-Oxo-2-<i>p</i>-substituted-phenylethylthio)-1,3,4-thiadiazol-2yl}-3′-methylpiperazinyl] Quinolone Derivatives

Synthesis and Antibacterial, Antimycobacterial Activity of 7-[4-{5-(2-Oxo-2-p-substituted-phenylethylthio)-1,3,4-thiadiazol-2yl}-3′-methylpiperazinyl] Quinolone Derivatives