Design, Synthesis, and Acetylcholinesterase Inhibition Assay of Novel 9‐(1‐(Substituted‐benzyl)piperidin‐4‐yl)‐2‐chloro‐9H‐purin‐6‐amine Derivatives | Zendy

Dongwei Kang | Zendy; Yuning Song | Zendy; Peng Zhan | Zendy; Qingzhu Zhang | Zendy; Xinyong Liu | Zendy

Open Access

Design, Synthesis, and Acetylcholinesterase Inhibition Assay of Novel 9‐(1‐(Substituted‐benzyl)piperidin‐4‐yl)‐2‐chloro‐9H‐purin‐6‐amine Derivatives

Author(s) -

Dongwei Kang,

Yuning Song,

Peng Zhan,

Qingzhu Zhang,

Xinyong Liu

Publication year - 2013

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.436

H-Index - 50

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2013/107302

Subject(s) - chemistry , acetylcholinesterase , amine gas treating , aché , inhibitory postsynaptic potential , stereochemistry , proton nmr , enzyme , organic chemistry , medicine

A new series of 9-(1-(substituted-benzyl)piperidin-4-yl)-2-chloro-9H-purin-6-amine derivatives were designed, synthesized, and characterized on the basis of 1H-NMR, 13C-NMR, and mass spectra. The newly synthesized compounds were evaluated for the inhibition activity against acetylcholinesterase (AChE). Biological results revealed that four compounds among them showed moderate activities against AChE with inhibitory percentage more than 10% at 100 μM. Further pharmacology investigation towards other pathological routes in AD is currently underway

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