Subversion of Immunity byLeishmania amazonensisParasites: Possible Role of Phosphatidylserine as a Main Regulator | Zendy

João Luiz Mendes Wanderley | Zendy; Jaqueline França Costa | Zendy; Valéria M. Borges | Zendy; Marcello A. Barcinski | Zendy

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Subversion of Immunity byLeishmania amazonensisParasites: Possible Role of Phosphatidylserine as a Main Regulator

Author(s) -

João Luiz Mendes Wanderley,

Jaqueline França Costa,

Valéria M. Borges,

Marcello A. Barcinski

Publication year - 2012

Publication title -

journal of parasitology research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.46

H-Index - 27

eISSN - 2090-0031

pISSN - 2090-0023

DOI - 10.1155/2012/981686

Subject(s) - leishmania , regulator , subversion , biology , immunity , immunology , phosphatidylserine , innate immune system , immune system , mechanism (biology) , acquired immune system , leishmaniasis , microbiology and biotechnology , parasite hosting , genetics , phospholipid , philosophy , epistemology , membrane , world wide web , computer science , politics , political science , law , gene

Leishmania amazonensis parasites cause progressive disease in most inbred mouse strains and are associated with the development of diffuse cutaneous leishmaniasis in humans. The poor activation of an effective cellular response is correlated with the ability of these parasites to infect mononuclear phagocytic cells without triggering their activation or actively suppressing innate responses of these cells. Here we discuss the possible role of phosphatidylserine exposure by these parasites as a main regulator of the mechanism underlying subversion of the immune system at different steps during the infection.

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