Blueberry Extracts Protect Testis from Hypobaric Hypoxia Induced Oxidative Stress in Rats | Zendy

Andrea Zepeda | Zendy; Luis G. Aguayo | Zendy; Jorge Fuentealba | Zendy; Carolina A. Figueroa | Zendy; Alejandro Acevedo | Zendy; Perla Salgado | Zendy; Gloria M. Calaf | Zendy; Jorge G. Farías | Zendy

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Blueberry Extracts Protect Testis from Hypobaric Hypoxia Induced Oxidative Stress in Rats

Author(s) -

Andrea Zepeda,

Luis G. Aguayo,

Jorge Fuentealba,

Carolina A. Figueroa,

Alejandro Acevedo,

Perla Salgado,

Gloria M. Calaf,

Jorge G. Farías

Publication year - 2012

Publication title -

oxidative medicine and cellular longevity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.494

H-Index - 93

eISSN - 1942-0900

pISSN - 1942-0994

DOI - 10.1155/2012/975870

Subject(s) - oxidative stress , superoxide dismutase , lipid peroxidation , glutathione reductase , glutathione , hypoxia (environmental) , biology , reactive oxygen species , oxidative damage , chemistry , endocrinology , biochemistry , glutathione peroxidase , enzyme , oxygen , organic chemistry

Exposure to hypobaric hypoxia causes oxidative damage to male rat reproductive function. The aim of this study was to evaluate the protective effect of a blueberry extract (BB-4) in testis of rats exposed to hypobaric hypoxia. Morphometric analysis, cellular DNA fragmentation, glutathione reductase (GR), and superoxide dismutase (SOD) activities were evaluated. Our results showed that supplementation of BB-4 reduced lipid peroxidation, decreased apoptosis, and increased GR and SOD activities in rat testis under hypobaric hypoxia conditions . Therefore, this study demonstrates that blueberry extract significantly reduced the harmful effects of oxidative stress caused by hypobaric hypoxia in rat testis by affecting glutathione reductase and superoxide dismutase activities

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