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Peroxisome proliferator-activated receptor   α   is a member of the nuclear receptor superfamily. It modulates smooth muscle cell proliferation and inflammatory cytokines in vitro. In this study, we tested the hypothesis that PPAR  α   would decrease the expression of monocyte chemoattractant protein-1 and tissue factor, and inhibit neointimal formation in a murine double carotid artery injury model. Carotid artery injury was performed in the PPAR  α   knockout and wild type (WT) mice, treated and untreated with Wy14643, a PPAR  α   activator. Up-regulated MCP-1 and TF expression and more neointimal formation were observed in the PPAR  α    −/−  mice compared with WT mice. The activation of PPAR  α   resulted in further decreased neointimal formation. Our data further suggest that the decrease in neointimal formation is due to down-regulation of MCP-1 by PPAR  α   resulting in decreased leukocyte infiltration and TF expression.

ppar research

Peroxisome Proliferator-Activated Receptor<i>α</i>Plays an Important Role in the Expression of Monocyte Chemoattractant Protein-1 and Neointimal Hyperplasia after Vascular Injury

Peroxisome Proliferator-Activated ReceptorαPlays an Important Role in the Expression of Monocyte Chemoattractant Protein-1 and Neointimal Hyperplasia after Vascular Injury