Disposition Kinetics of Taxanes in Peritoneal Dissemination | Zendy

Kenichi Miyamoto | Zendy; Tsutomu Shimada | Zendy; Kazuki Sawamoto | Zendy; Yoshimichi Sai | Zendy; Yutaka Yonemura | Zendy

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Disposition Kinetics of Taxanes in Peritoneal Dissemination

Author(s) -

Kenichi Miyamoto,

Tsutomu Shimada,

Kazuki Sawamoto,

Yoshimichi Sai,

Yutaka Yonemura

Publication year - 2012

Publication title -

gastroenterology research and practice

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.622

H-Index - 45

eISSN - 1687-630X

pISSN - 1687-6121

DOI - 10.1155/2012/963403

Subject(s) - docetaxel , medicine , taxane , paclitaxel , peritoneal cavity , pharmacology , cancer , breast cancer , surgery

Treatment of cancers in the abdominal cavity, such as peritoneal dissemination, is difficult, but in principle intraperitoneal administration of anticancer drugs is expected to be preferable to systemic administration. Taxane anticancer drugs are used to treat gastric cancer patients with peritoneal dissemination. They are administered as micellar preparations, Taxol and Taxotere, which consist of paclitaxel in Cremophor EL (crEL) and docetaxel in Polysorbate-80 (PS-80), respectively. In this paper we review the disposition kinetics of taxane anticancer drugs after intraperitoneal administration in peritoneal dissemination patients and animal models and also discuss the effect of the surfactant vehicle on the behavior of taxanes.

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