Th17 Mediated Alloreactivity Is Facilitated by the Pre-Transplant Microbial Burden of the Recipient | Zendy

Aleksandra Klimczak | Zendy; Andrzej Lange | Zendy

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Th17 Mediated Alloreactivity Is Facilitated by the Pre-Transplant Microbial Burden of the Recipient

Author(s) -

Aleksandra Klimczak,

Andrzej Lange

Publication year - 2012

Publication title -

bone marrow research

Language(s) - English

Resource type - Journals

eISSN - 2090-2999

pISSN - 2090-3006

DOI - 10.1155/2012/960280

Subject(s) - medicine , immunology , hematopoietic stem cell transplantation , disease , immunity , transplantation , graft versus host disease , acquired immune system , haematopoiesis , immune system , innate immune system , stem cell , biology , genetics

Acute graft-versus-host disease (aGvHD) is a major complication after hematopoietic stem cell transplantation (HSCT) and severity of aGvHD is associated with biological and genetic factors related to donors and recipients. Studies on inflammatory pathways involved in aGvHD have shown a significant impact of the gut microflora on aGvHD development giving increasing evidence in the understanding of the response of innate and adaptive immunity to microbial products. Cytokine deregulation may increase or reduce the risk of aGvHD. Damage of tissues affected by aGvHD reflects the immunological cascade of events in this disease.

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