A Fatal Case of Nafcillin-Induced Hepatotoxicity: A Case Report and the Literature Review | Zendy

Mian Bilal Alam | Zendy; Amin Kadoura | Zendy; Magesh Sathaiah | Zendy

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A Fatal Case of Nafcillin-Induced Hepatotoxicity: A Case Report and the Literature Review

Author(s) -

Mian Bilal Alam,

Amin Kadoura,

Magesh Sathaiah

Publication year - 2012

Publication title -

case reports in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.2

H-Index - 20

eISSN - 1687-9627

pISSN - 1687-9635

DOI - 10.1155/2012/953714

Subject(s) - medicine , nafcillin , fulminant hepatic failure , subclinical infection , drug , bilirubin , liver injury , etiology , fulminant , gastroenterology , antibiotics , liver transplantation , pharmacology , penicillin , biology , transplantation , microbiology and biotechnology

Background . Drug-induced hepatotoxicity (DIH) is quite common, and there are several recommendations for its treatment based upon its etiology. DIH may range from mild and subclinical to fulminant liver failure and death. Even though there is extensive list of drugs causing DIH, antibiotics, as a class of drugs, are the most common cause of DIH. Here, we present a fatal case of nafcillin-induced hepatotoxicity confirmed by liver biopsy, with total bilirubin peaking to 21.8 mg/dl and subsequent further extensive evaluation for hepatic injury turning out to be negative.

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