Clinical Features, Pathophysiology, and Treatment of Levodopa-Induced Dyskinesias in Parkinson’s Disease | Zendy

Jorge Guridi | Zendy; R. Reina Gonzalez | Zendy; José Á. Obeso | Zendy

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Clinical Features, Pathophysiology, and Treatment of Levodopa-Induced Dyskinesias in Parkinson’s Disease

Author(s) -

Jorge Guridi,

R. Reina Gonzalez,

José Á. Obeso

Publication year - 2012

Publication title -

parkinson s disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.748

H-Index - 46

eISSN - 2090-8083

pISSN - 2042-0080

DOI - 10.1155/2012/943159

Subject(s) - levodopa , pathophysiology , dyskinesia , parkinson's disease , movement disorders , disease , medicine , motor symptoms , physical medicine and rehabilitation , neuroscience , psychology

Dyskinetic disorders are characterized by excess of motor activity that may interfere with normal movement control. In patients with Parkinson's disease, the chronic levodopa treatment induces dyskinetic movements known as levodopa-induced dyskinesias (LID). This paper analyzed the pathophysiology, clinical manifestations, pharmacological treatments, and surgical procedures to treat hyperkinetic disorders. Surgery is currently the only treatment available for Parkinson's disease that may improve both parkinsonian motor syndrome and LID. However, this paper shows the different mechanisms involved are not well understood.

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