Cephazolin-Induced Toxic Epidermal Necrolysis Treated with Intravenous Immunoglobulin and N-Acetylcysteine | Zendy

Carlos Saavedra | Zendy; Paola Andrea Cárdenas | Zendy; Héctor José Castellanos | Zendy; Kateir Contreras | Zendy; Juan Raúl Castro-Ayarza | Zendy

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Cephazolin-Induced Toxic Epidermal Necrolysis Treated with Intravenous Immunoglobulin and N-Acetylcysteine

Author(s) -

Carlos Saavedra,

Paola Andrea Cárdenas,

Héctor José Castellanos,

Kateir Contreras,

Juan Raúl Castro-Ayarza

Publication year - 2012

Publication title -

case reports in immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.125

H-Index - 3

eISSN - 2090-6609

pISSN - 2090-6617

DOI - 10.1155/2012/931528

Subject(s) - toxic epidermal necrolysis , acetylcysteine , medicine , antibody , total body surface area , dermatology , pharmacology , immunology , chemistry , antioxidant , biochemistry

Toxic epidermal necrolysis is the most severe form of drug-induced skin reaction and includes denudation of >30% of total body surface area. The mechanism of disease is not completely understood, but immunologic mechanisms, cytotoxic reactions, and delayed hypersensitivity seem to be involved. We report a case of cephazolin-induced toxic epidermal necrolysis treated with intravenous immunoglobulin and N-acetylcysteine with excellent response.

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