ETosis: A Microbicidal Mechanism beyond Cell Death | Zendy

Anderson B. Guimarães-Costa | Zendy; Michelle T. C. Nascimento | Zendy; Amanda Brito Wardini | Zendy; Lucia Helena Pinto-da-Silva | Zendy; Elvira M. Saraiva | Zendy

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ETosis: A Microbicidal Mechanism beyond Cell Death

Author(s) -

Anderson B. Guimarães-Costa,

Michelle T. C. Nascimento,

Amanda Brito Wardini,

Lucia Helena Pinto-da-Silva,

Elvira M. Saraiva

Publication year - 2012

Publication title -

journal of parasitology research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.46

H-Index - 27

eISSN - 2090-0031

pISSN - 2090-0023

DOI - 10.1155/2012/929743

Subject(s) - neutrophil extracellular traps , extracellular , programmed cell death , cytoplasm , microbiology and biotechnology , mechanism (biology) , histone , biology , mast cell , dna , chemistry , immunology , inflammation , apoptosis , biochemistry , physics , quantum mechanics

Netosis is a recently described type of neutrophil death occurring with the release to the extracellular milieu of a lattice composed of DNA associated with histones and granular and cytoplasmic proteins. These webs, initially named neutrophil extracellular traps (NETs), ensnare and kill microorganisms. Similarly, other cell types, such as eosinophils, mast cells, and macrophages, can also dye by this mechanism; thus, it was renamed as ETosis, meaning death with release of extracellular traps (ETs). Here, we review the mechanism of NETosis/etosis, emphasizing its role in diseases caused by protozoan parasites, fungi, and viruses.

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