Management of Calcium Channel Antagonist Overdose with Hyperinsulinemia-Euglycemia Therapy: Case Series and Review of the Literature | Zendy

Shiwan K. Shah | Zendy; Sanjeev Kumar Goswami | Zendy; Rajesh V. Babu | Zendy; Gulshan Sharma | Zendy; Alexander G. Duarte | Zendy

Open Access

Management of Calcium Channel Antagonist Overdose with Hyperinsulinemia-Euglycemia Therapy: Case Series and Review of the Literature

Author(s) -

Shiwan K. Shah,

Sanjeev Kumar Goswami,

Rajesh V. Babu,

Gulshan Sharma,

Alexander G. Duarte

Publication year - 2012

Publication title -

case reports in critical care

Language(s) - English

Resource type - Journals

eISSN - 2090-6439

pISSN - 2090-6420

DOI - 10.1155/2012/927040

Subject(s) - hyperinsulinemia , medicine , calcium channel , resuscitation , calcium , insulin , intensive care medicine , pharmacology , anesthesia , insulin resistance

Calcium channel antagonists (CCAs) are commonly involved in drug overdoses. Standard approaches to the management of CCA overdoses, including fluid resuscitation, gut decontamination, administration of calcium, glucagon, and atropine, as well as supportive care, are often ineffective. We report on two patients who improved after addition of hyperinsulinemia-euglycemia (HIE) therapy. We conclude with a literature review on hyperinsulinemia-euglycemia therapy with an exploration of the physiology behind its potential use.

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