Light-Emitting Diode-Based Illumination System forIn VitroPhotodynamic Therapy | Zendy

Defu Chen | Zendy; Hui-fen Zheng | Zendy; Zhiyong Huang | Zendy; Huiyun Lin | Zendy; Zhidong Ke | Zendy; Shusen Xie | Zendy; Buhong Li | Zendy

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Light-Emitting Diode-Based Illumination System forIn VitroPhotodynamic Therapy

Author(s) -

Defu Chen,

Hui-fen Zheng,

Zhiyong Huang,

Huiyun Lin,

Zhidong Ke,

Shusen Xie,

Buhong Li

Publication year - 2012

Publication title -

international journal of photoenergy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.426

H-Index - 51

eISSN - 1687-529X

pISSN - 1110-662X

DOI - 10.1155/2012/920671

Subject(s) - photodynamic therapy , irradiation , optoelectronics , light emitting diode , irradiance , materials science , diode , optics , homogeneity (statistics) , light source , in vitro , photosensitizer , biomedical engineering , chemistry , photochemistry , computer science , medicine , physics , biochemistry , machine learning , nuclear physics , organic chemistry

The aim of this study is to develop a light-emitting diode- (LED-) based illumination system that can be used as an alternative light source for in vitro photodynamic therapy (PDT). This illumination system includes a red LED array composed of 70 LEDs centered at 643 nm, an air-cooling unit, and a specific-designed case. The irradiance as a function of the irradiation distance between the LED array and the sample, the homogeneity and stability of irradiation, and the effect of long-time irradiation on culture medium temperature were characterized. Furthermore, the survival rate of the CNE1 cells that sensitized with 5-aminolevulinic acid after PDT treatment was evaluated to demonstrate the efficiency of the new LED-based illumination system. The obtained results show that the LED-based illumination system is a promising light source for in vitro PDT that performed in standard multiwell plate.

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