Renal Development and Blood Pressure in Offspring from Dams Submitted to High-Sodium Intake during Pregnancy and Lactation | Zendy

Terezila Machado Coimbra | Zendy; Heloı́sa Della Coletta Francescato | Zendy; Ana Paula Coelho Balbi | Zendy; Evelyn Cristina Santana Marin | Zendy; Roberto Silva Costa | Zendy

Open Access

Renal Development and Blood Pressure in Offspring from Dams Submitted to High-Sodium Intake during Pregnancy and Lactation

Author(s) -

Terezila Machado Coimbra,

Heloı́sa Della Coletta Francescato,

Ana Paula Coelho Balbi,

Evelyn Cristina Santana Marin,

Roberto Silva Costa

Publication year - 2012

Publication title -

international journal of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.551

H-Index - 29

eISSN - 2090-2158

pISSN - 2090-214X

DOI - 10.1155/2012/919128

Subject(s) - medicine , offspring , lactation , pregnancy , blood pressure , high sodium , physiology , high pressure , fluid intake , obstetrics , endocrinology , biology , genetics , engineering physics , engineering

Exposure to an adverse environment in utero appears to programme physiology and metabolism permanently, with long-term consequences for health of the fetus or offspring. It was observed that the offspring from dams submitted to high-sodium intake during pregnancy present disturbances in renal development and in blood pressure. These alterations were associated with lower plasma levels of angiotensin II (AII) and changes in renal AII receptor I (AT1) and mitogen-activated protein kinase (MAPK) expressions during post natal kidney development. Clinical and experimental evidence show that the renin-angiotensin system (RAS) participates in renal development. Many effects of AII are mediated through MAPK pathways. Extracellular signal-regulated protein kinases (ERKs) play a pivotal role in cellular proliferation and differentiation. In conclusion, high-sodium intake during pregnancy and lactation can provoke disturbances in renal development in offspring leading to functional and structural alterations that persist in adult life. These changes can be related at least in part with the decrease in RAS activity considering that this system has an important role in renal development

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