Polymorphisms and Haplotypes in Candidate Genes Related to Angiogenesis and Endothelial Dysfunction in Preeclampsia | Zendy

Marcelo R. Luizon | Zendy; Ana C. Palei | Zendy; Valéria C. Sandrim | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Polymorphisms and Haplotypes in Candidate Genes Related to Angiogenesis and Endothelial Dysfunction in Preeclampsia

Author(s) -

Marcelo R. Luizon,

Ana C. Palei,

Valéria C. Sandrim

Publication year - 2012

Publication title -

journal of pregnancy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.828

H-Index - 32

eISSN - 2090-2735

pISSN - 2090-2727

DOI - 10.1155/2012/914704

Subject(s) - haplotype , preeclampsia , candidate gene , angiogenesis , endothelial dysfunction , gene , genetics , genotype , medicine , population , bioinformatics , immunology , biology , pregnancy , environmental health

Valenzuela and colleagues have recently reviewed some polymorphisms in important candidate genes involved in different pathogenic mechanisms related to preeclampsia (PE) and concluded that various studies in different populations have identified maternal polymorphisms associated with PE. However, we would like to contribute to some studies regarding candidate genes related to angiogenesis and endothelial dysfunction in PE performed in the Brazilian population. Specifically, genotypes and haplotypes formed by polymorphisms of VEGF , eNOS and MMP-9 , along with an example of the interaction among these genes in the prediction of PE. Our suggestions may provide additional information with clinical relevance to PE susceptibility.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research