Biochemical Alterations in Semen of Varicocele Patients: A Review of the Literature | Zendy

Antonio Mancini | Zendy; Roberto Festa | Zendy; Sebastiano Raimondo | Zendy; Andrea Silvestrini | Zendy; E. Giacchi | Zendy; Gian Paolo Littarru | Zendy; Alfredo Pontecorvi | Zendy; Elisabetta Meucci | Zendy

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Biochemical Alterations in Semen of Varicocele Patients: A Review of the Literature

Author(s) -

Antonio Mancini,

Roberto Festa,

Sebastiano Raimondo,

Andrea Silvestrini,

E. Giacchi,

Gian Paolo Littarru,

Alfredo Pontecorvi,

Elisabetta Meucci

Publication year - 2011

Publication title -

advances in urology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.18

H-Index - 30

eISSN - 1687-6377

pISSN - 1687-6369

DOI - 10.1155/2012/903931

Subject(s) - varicocele , oxidative stress , semen , medicine , infertility , male infertility , mechanism (biology) , semen analysis , sperm , hormone , physiology , andrology , bioinformatics , endocrinology , biology , genetics , pregnancy , philosophy , epistemology

Oxidative stress is a mechanism underlying different kinds of infertility in human males. However, different results can be observed in relation to the method used for its evaluation. Varicocele patients show a number of biochemical abnormalities, including an altered distribution of coenzyme Q between seminal plasma and sperm cells and also an apparent defect in the utilization of antioxidants. Moreover, an influence of systemic hormones on seminal antioxidant system was observed too. Finally, the effects of surgical treatment on oxidativestress indexes and the possible usefulness of some medical therapies, like coenzyme Q supplementation, are discussed. In conclusion, published data show a role of oxidative stress in varicocele-related male infertility, but at present we do not know the precise molecular mechanisms underlying these phenomena.

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