Synthesis and Antimicrobial Activity of Some New 1, 4-Benzothiazine Containing Thiosemicarbazides and 1, 3, 4-Oxadiazole Derivatives | Zendy

Bhikan J. Khairnar | Zendy; Rahul S. Salunke | Zendy; Premchand B. Patil | Zendy; Sanjay A . Patil | Zendy; Rajeshwar J . Kapade | Zendy; Pravin S. Girase | Zendy; Bhata R. Chaudhari | Zendy

Open Access

Synthesis and Antimicrobial Activity of Some New 1, 4-Benzothiazine Containing Thiosemicarbazides and 1, 3, 4-Oxadiazole Derivatives

Author(s) -

Bhikan J. Khairnar,

Rahul S. Salunke,

Premchand B. Patil,

Sanjay A . Patil,

Rajeshwar J . Kapade,

Pravin S. Girase,

Bhata R. Chaudhari

Publication year - 2011

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2012/902784

Subject(s) - benzothiazine , antimicrobial , chemistry , oxadiazole , radiochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry

A series of novel 3- methyl-7-substituted-4H,4-benzothiazine-2-carbohydrazide (3a-e) and corresponding thiosemicarbazides (4-a-q); 2-[3-methyl-7-substituted- 4H -1, 4-benzothiazine-2-yl]-N-(aryl) hydrazine carbothiamide have been synthesized. The thiosemicarbazide when cyclized with iodine via intramolecular cyclisation gave benzothiazonyl oxadiazoles (5-a-q); 5-(3-methyl -7-substitued-4H- 1,4-benzothiazin-2-yl)- N —aryl- 1,3,4- oxadiazol -2-amine and the compounds were tested for antibacterial and antifungal activities against different microorganisms

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