Voltammetric Determination of Homocysteine Using Multiwall Carbon Nanotube Paste Electrode in the Presence of Chlorpromazine as a Mediator | Zendy

Fathali GholamiOrimi | Zendy; F. Taleshi | Zendy; Pourya Biparva | Zendy; Hassan KarimiMaleh | Zendy; Hadi Beitollahi | Zendy; Hamid Reza Ebrahimi | Zendy; Mohamad Shamshiri | Zendy; Hasan Bagheri | Zendy; Masoud Fouladgar | Zendy; Ali Taherkhani | Zendy

Open Access

Voltammetric Determination of Homocysteine Using Multiwall Carbon Nanotube Paste Electrode in the Presence of Chlorpromazine as a Mediator

Author(s) -

Fathali GholamiOrimi,

F. Taleshi,

Pourya Biparva,

Hassan KarimiMaleh,

Hadi Beitollahi,

Hamid Reza Ebrahimi,

Mohamad Shamshiri,

Hasan Bagheri,

Masoud Fouladgar,

Ali Taherkhani

Publication year - 2012

Publication title -

journal of analytical methods in chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.407

H-Index - 25

eISSN - 2090-8865

pISSN - 2090-8873

DOI - 10.1155/2012/902184

Subject(s) - carbon nanotube , electrode , mediator , materials science , chlorpromazine , homocysteine , composite material , biomedical engineering , chemistry , pharmacology , medicine , biochemistry

We propose chlorpromazine (CHP) as a new mediator for the rapid, sensitive, and highly selective voltammetric determination of homocysteine (Hcy) using multiwall carbon nanotube paste electrode (MWCNTPE). The experimental results showed that the carbon nanotube paste electrode has a highly electrocatalytic activity for the oxidation of Hcy in the presence of CHP as a mediator. Cyclic voltammetry, double potential step chronoamperometry, and square wave voltammetry (SWV) are used to investigate the suitability of CHP at the surface of MWCNTPE as a mediator for the electrocatalytic oxidation of Hcy in aqueous solutions. The kinetic parameters of the system, including electron transfer coefficient, and catalytic rate constant were also determined using the electrochemical approaches. In addition, SWV was used for quantitative analysis. SWV showed wide linear dynamic range (0.1–210.0 μ M Hcy) with a detection limit of 0.08 μ M Hcy. Finally, this method was also examined as a selective, simple, and precise electrochemical sensor for the determination of Hcy in real samples.

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