Fetuin-A Characteristics during and after Pregnancy: Result from a Case Control Pilot Study | Zendy

Serdar Farhan | Zendy; Ammon Handisurya | Zendy; Jelena Todoric | Zendy; Andrea Tura | Zendy; Giovanni Pacini | Zendy; Oswald Wagner | Zendy; Katharina Klein | Zendy; Rudolf Járai | Zendy; Kurt Huber | Zendy; Alexandra KautzkyWiller | Zendy

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Fetuin-A Characteristics during and after Pregnancy: Result from a Case Control Pilot Study

Author(s) -

Serdar Farhan,

Ammon Handisurya,

Jelena Todoric,

Andrea Tura,

Giovanni Pacini,

Oswald Wagner,

Katharina Klein,

Rudolf Járai,

Kurt Huber,

Alexandra KautzkyWiller

Publication year - 2012

Publication title -

international journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.875

H-Index - 60

eISSN - 1687-8345

pISSN - 1687-8337

DOI - 10.1155/2012/896736

Subject(s) - medicine , gestational diabetes , postprandial , pregnancy , fetuin , endocrinology , body mass index , gestation , diabetes mellitus , insulin , obstetrics , genetics , microbiology and biotechnology , glycoprotein , biology

Objective . Fetuin-A has been associated with gestational diabetes mellitus (GDM). We investigated fetuin-A levels during and after pregnancy in women with GDM. Fetuin-A measurements were performed in 10 women with GDM and 10 age and body mass index (BMI) matched healthy pregnant women. All women underwent an oral glucose tolerance test (OGTT) in and 3 months after gestation. Results . Fasting fetuin-A correlated with BMI in women with former GDM ( r = 0.90, P < 0.0001) but showed no association with parameters of glucose tolerance in women with GDM or post-GDM. GDM featured significantly lower insulin sensitivity and higher insulin and C-peptide secretion profiles compared to NGT during pregnancy ( P < 0.05). Fasting and postprandial fetuin-A did not differ between groups, neither during nor after pregnancy. Conclusion . Fetuin-A is not influenced by glucose tolerance during or after pregnancy or acute glucose elevations following glucose ingestion in young women, but closely relates to BMI early postpartum.

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