Extracellular NM23 Protein as a Therapeutic Target for Hematologic Malignancies | Zendy

Junko OkabeKado | Zendy; Takashi Kasukabe | Zendy; Yasuhiko Kaneko | Zendy

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Extracellular NM23 Protein as a Therapeutic Target for Hematologic Malignancies

Author(s) -

Junko OkabeKado,

Takashi Kasukabe,

Yasuhiko Kaneko

Publication year - 2011

Publication title -

advances in hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.371

H-Index - 31

eISSN - 1687-9112

pISSN - 1687-9104

DOI - 10.1155/2012/879368

Subject(s) - extracellular , medicine , mapk/erk pathway , leukemia , cancer research , in vitro , kinase , signal transduction , cytokine , immunology , microbiology and biotechnology , biology , biochemistry

An elevated serum level of NM23-H1 protein is a poor prognostic factor in patients with various hematologic malignancies. The extracellular NM23-H1 protein promotes the in vitro growth and survival of acute myelogenous leukemia (AML) cells and inversely inhibits the in vitro survival of normal peripheral blood monocytes in primary culture at concentrations equivalent to the levels found in the serum of AML patients. The growth and survival promoting activity to AML cells is associated with cytokine production and activation of mitogen-activated protein kinases (MAPKs) and signal transducers and activators of transcription (STAT) signaling pathways. Inhibitors specific for MAPK signaling pathways inhibit the growth/survival-promoting activity of NM23-H1. These findings indicate a novel biological action of extracellular NM23-H1 and its association with poor prognosis. These results suggest an important role of extracellular NM23-H1 in the malignant progression of leukemia and a potential therapeutic target for these malignancies.

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