Open AccessHydrogen Sulfide as an Endogenous Modulator in Mitochondria and Mitochondria Dysfunction
Author(s) -
Wei Guo,
Juntao Kan,
Ze-yu Cheng,
Jiefang Chen,
Yaqi Shen,
Jie Xu,
Dan Wu,
Yi Zhun Zhu
Publication year - 2012
Publication title -
oxidative medicine and cellular longevity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.494
H-Index - 93
eISSN - 1942-0900
pISSN - 1942-0994
DOI - 10.1155/2012/878052
Subject(s) - mitochondrion , phenylarsine oxide , hydrogen sulfide , endogeny , cytoprotection , microbiology and biotechnology , chemistry , cystathionine beta synthase , biochemistry , biophysics , biology , oxidative stress , receptor , cysteine , enzyme , sulfur , organic chemistry
Hydrogen sulfide (H2S) has historically been considered to be a toxic gas, an environmental and occupational hazard. However, with the discovery of its presence and enzymatic production through precursors of L-cysteine and homocysteine in mammalian tissues, H2S has recently received much interest as a physiological signaling molecule. H2S is a gaseous messenger molecule that has been implicated in various physiological and pathological processes in mammals, including vascular relaxation, angiogenesis, and the function of ion channels, ischemia/reperfusion (I/R), and heart injury. H2S is an endogenous neuromodulator and present studies show that physiological concentrations of H2S enhance NMDA receptor-mediated responses and aid in the induction of hippocampal long-term potentiation. Moreover, in the field of neuronal protection, physiological concentrations of H2S in mitochondria have many favorable effects on cytoprotection
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom