Evaluation of a Novel Rapid Test System for the Detection of Specific IgE to Hymenoptera Venoms | Zendy

Nikolai Pfender | Zendy; Ralf Lucassen | Zendy; Nadine Offermann | Zendy; Johannes Schulte-Pelkum | Zendy; Margrit Fooke | Zendy; Thilo Jakob | Zendy

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Evaluation of a Novel Rapid Test System for the Detection of Specific IgE to Hymenoptera Venoms

Author(s) -

Nikolai Pfender,

Ralf Lucassen,

Nadine Offermann,

Johannes Schulte-Pelkum,

Margrit Fooke,

Thilo Jakob

Publication year - 2012

Publication title -

journal of allergy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.39

H-Index - 3

eISSN - 1687-9791

pISSN - 1687-9783

DOI - 10.1155/2012/862023

Subject(s) - venom , allergy , immunoglobulin e , medicine , immunology , biology , antibody , ecology

Background . The Allergy Lateral Flow Assay (ALFA) is a novel rapid assay for the detection of sIgE to allergens. The objective of this study is the evaluation of ALFA for the detection of sIgE to bee venom (BV) and wasp venom (WV) in insect venom allergic patients. Methods . Specific IgE to BV and WV was analyzed by ALFA, ALLERG-O-LIQ, and ImmunoCAP in 80 insect venom allergic patients and 60 control sera. Sensitivity and specificity of ALFA and correlation of ALFA and ImmunoCAP results were calculated. Results . The sensitivity/specificity of ALFA to the diagnosis was 100%/83% for BV and 82%/97% for WV. For insect venom allergic patients, the Spearman correlation coefficient for ALFA versus ImmunoCAP was 0.79 for BV and 0.80 for WV. However, significant differences in the negative control groups were observed. Conclusion . ALFA represents a simple, robust, and reliable tool for the rapid detection of sIgE to insect venoms.

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