Thymoquinone, theNigella sativaBioactive Compound, Prevents Circulatory Oxidative Stress Caused by 1,2-Dimethylhydrazine in Erythrocyte during Colon Postinitiation Carcinogenesis | Zendy

Hanene Jrah Harzallah | Zendy; Rahma Grayaa | Zendy; Wafa Kharoubi | Zendy; Aya Maaloul | Zendy; Mohamed Hammami | Zendy; Touhami Mahjoub | Zendy

Open Access

Thymoquinone, theNigella sativaBioactive Compound, Prevents Circulatory Oxidative Stress Caused by 1,2-Dimethylhydrazine in Erythrocyte during Colon Postinitiation Carcinogenesis

Author(s) -

Hanene Jrah Harzallah,

Rahma Grayaa,

Wafa Kharoubi,

Aya Maaloul,

Mohamed Hammami,

Touhami Mahjoub

Publication year - 2012

Publication title -

oxidative medicine and cellular longevity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.494

H-Index - 93

eISSN - 1942-0900

pISSN - 1942-0994

DOI - 10.1155/2012/854065

Subject(s) - thymoquinone , malondialdehyde , oxidative stress , superoxide dismutase , nigella sativa , 1,2 dimethylhydrazine , lipid peroxidation , catalase , chemistry , antioxidant , pharmacology , glutathione peroxidase , pro oxidant , glutathione , biochemistry , medicine , carcinogenesis , enzyme , traditional medicine , azoxymethane , gene

We have performed this study to investigate the modulatory effect of thymoquinone (TQ), the Nigella sativa active compound, on erythrocyte lipid peroxidation and antioxidant status during 1,2-dimethylhydrazine- (DMH-) induced colon carcinogenesis after initiation in male Wistar rats.Rats exposed to DMH showed an increase of malondialdehyde and conjugated diene levels, and an augmentation of enzyme activities like catalase, glutathione peroxidase, and superoxide dismutase activities was also noted. The TQ pretreatment restored the parameters cited above to near-normal values. However, the posttreatment shows an activity similar as that presented by DMH. Therefore, our investigation revealed that TQ was a useful compound preventing DMH-induced erythrocyte damages

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