PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis | Zendy

Naoko Okumura | Zendy; Hitomi Yoshida | Zendy; Yasuko Kitagishi | Zendy; Mutsumi Murakami | Zendy; Yuri Nishimura | Zendy; Satoru Matsuda | Zendy

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PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis

Author(s) -

Naoko Okumura,

Hitomi Yoshida,

Yasuko Kitagishi,

Mutsumi Murakami,

Yuri Nishimura,

Satoru Matsuda

Publication year - 2012

Publication title -

advances in hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.371

H-Index - 31

eISSN - 1687-9112

pISSN - 1687-9104

DOI - 10.1155/2012/843085

Subject(s) - pten , angiogenesis , pi3k/akt/mtor pathway , cancer research , protein kinase b , leukemia , signal transduction , medicine , microbiology and biotechnology , immunology , biology

PI3K/AKT/PTEN pathway is important in the regulation of angiogenesis mediated by vascular endothelial growth factor in many tumors including leukemia. The signaling pathway is activated in leukemia patients as well as leukemia cell lines together with a decrease in the expression of PTEN gene. The mechanism by which the signaling pathway regulates angiogenesis remains to be further elucidated. However, it has become an attractive target for drug therapy against leukemia, because angiogenesis is a key process in malignant cell growth. In this paper, we will focus on the roles and mechanisms of PI3K/AKT/PTEN pathway in regulating angiogenesis.

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