How the Interval between Prime and Boost Injection Affects the Immune Response in a Computational Model of the Immune System | Zendy

Filippo Castiglione | Zendy; Francesca Mantile | Zendy; Piergiuseppe De Berardinis | Zendy; Antonella Prisco | Zendy

Open Access

How the Interval between Prime and Boost Injection Affects the Immune Response in a Computational Model of the Immune System

Author(s) -

Filippo Castiglione,

Francesca Mantile,

Piergiuseppe De Berardinis,

Antonella Prisco

Publication year - 2012

Publication title -

computational and mathematical methods in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.462

H-Index - 48

eISSN - 1748-6718

pISSN - 1748-670X

DOI - 10.1155/2012/842329

Subject(s) - immune system , priming (agriculture) , interval (graph theory) , vaccination , prime (order theory) , antibody titer , antibody , antibody response , immunology , titer , computer science , antigen , mathematics , medicine , biology , combinatorics , botany , germination

The immune system is able to respond more vigorously to the second contact with a given antigen than to the first contact. Vaccination protocols generally include at least two doses, in order to obtain high antibody titers. We want to analyze the relation between the time elapsed from the first dose (priming) and the second dose (boost) on the antibody titers. In this paper, we couple in vivo experiments with computer simulations to assess the effect of delaying the second injection. We observe that an interval of several weeks between the prime and the boost is necessary to obtain optimal antibody responses.

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