H3K79me3T80ph is a Novel Histone Dual Modification and a Mitotic Indicator in Melanoma | Zendy

Danielle R. Martinez | Zendy; Hunter W. Richards | Zendy; Qiushi Lin | Zendy; Carlos A. TorresCabala | Zendy; Víctor G. Prieto | Zendy; Jonathan L. Curry | Zendy; Estela E. Medrano | Zendy

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H3K79me3T80ph is a Novel Histone Dual Modification and a Mitotic Indicator in Melanoma

Author(s) -

Danielle R. Martinez,

Hunter W. Richards,

Qiushi Lin,

Carlos A. TorresCabala,

Víctor G. Prieto,

Jonathan L. Curry,

Estela E. Medrano

Publication year - 2012

Publication title -

journal of skin cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.309

H-Index - 10

eISSN - 2090-2905

pISSN - 2090-2913

DOI - 10.1155/2012/823534

Subject(s) - medicine , mitosis , dual (grammatical number) , histone , melanoma , cancer research , computational biology , microbiology and biotechnology , biology , biochemistry , dna , art , literature

The current study characterizes the mitosis-associated histone dual modification on the core of histone H3: trimethylation of histone H3 lysine 79 and simultaneous phosphorylation of H3 threonine 80 (H3K79me3T80ph). Through the use of protein and microscopy-based techniques, we find that H3K79me3T80ph shares a similar spatial and temporal regulation as H3S10ph but additionally requires methyltransferase activity. In addition, we find that Aurora kinase activity is necessary for the catalysis of H3K79me3T80ph in vivo . Finally, our analysis of H3K79me3T80ph using a tissue microarray indicates that H3K79me3T80ph marks a subset of primary cutaneous melanomas with metastatic potential indicating that H3K79me3T80ph may identify a subset of invasive melanomas with a more aggressive clinical behaviour.

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