Screening Tests of Reproductive Immunology in Systemic Lupus Erythematosus | Zendy

Z Ulčová-Gallová | Zendy; Alice Mocková | Zendy; Miroslava Čedíková | Zendy

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Screening Tests of Reproductive Immunology in Systemic Lupus Erythematosus

Author(s) -

Z Ulčová-Gallová,

Alice Mocková,

Miroslava Čedíková

Publication year - 2012

Publication title -

autoimmune diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.681

H-Index - 32

eISSN - 2090-0422

pISSN - 2090-0430

DOI - 10.1155/2012/812138

Subject(s) - cardiolipin , autoantibody , medicine , zona pellucida , immunology , antiphospholipid syndrome , reproductive immunology , zona pellucida glycoprotein , phosphatidyl choline , antibody , phosphatidic acid , biology , pregnancy , reproductive technology , biochemistry , phospholipid , genetics , embryo , lactation , membrane , oocyte

Female patients in reproductive age with systemic lupus erythematosus and fertility complications together are observed by rheumatologists, gynecologists, and reproductive immunologists. The paper notes the presence of autoantibodies to zona pellucida, to phospholipids (phosphatidyl serine, phosphatidyl ethanolamine, phosphatidyl inositol, phosphatidyl glycerol, phosphatidic acid, annexin V, beta-2 glycoprotein I, and cardiolipin) and of isoantibodies to sperm cells. Isoantibodies to sperm cells are not significantly predominant, but autoimmunity is well expressed in IgG positivity against phosphatidyl inositol, phosphatidyl ethanolamine, phosphatidyl serine, cardiolipin, and beta-2 glycoprotein I, as well as antizona pellucida antibodies in IgG isotype. According to the levels of autoantibodies we have to choose preventive treatment to protect mother and her foetus.

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