Fatal Hepatocellular Carcinoma in a Patient with Occult Hepatitis B Virus Infection following the Administration of R-CHOP for Diffuse Large B-Cell Lymphoma | Zendy

Vincenzo Pitini | Zendy; Massimo Rizzo | Zendy; Carmela Arrigo | Zendy; Patrizia Mondello | Zendy; Giuseppe Altavilla | Zendy

Open Access

Fatal Hepatocellular Carcinoma in a Patient with Occult Hepatitis B Virus Infection following the Administration of R-CHOP for Diffuse Large B-Cell Lymphoma

Author(s) -

Vincenzo Pitini,

Massimo Rizzo,

Carmela Arrigo,

Patrizia Mondello,

Giuseppe Altavilla

Publication year - 2012

Publication title -

case reports in hematology

Language(s) - English

Resource type - Journals

eISSN - 2090-6560

pISSN - 2090-6579

DOI - 10.1155/2012/803298

Subject(s) - medicine , occult , hepatocellular carcinoma , fulminant , hepatitis b virus , chop , lymphoma , fulminant hepatitis , rituximab , diffuse large b cell lymphoma , virology , virus , pathology , immunology , alternative medicine

Occult hepatitis B (OBI) is caused by a persistent low-level replication of HBV. Like overt HBV infection, OBI can be associated with the integration of HBV sequences into the host genome and has a substantial clinical relevance for patients who are severely immunosuppressed for long durations. We present the case of a patient with a diffuse large B-cell non-Hodgkin lymphoma and OBI who developed a hepatocellular carcinoma with a fulminant clinical course following the administration of rituximab plus CHOP.

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