Acute Myocardial Infarction Caused by Filgrastim: A Case Report | Zendy

Cemil Bilir | Zendy; Hüseyin Engin | Zendy; Yasemin Bakkal Temi | Zendy; Bilal Toka | Zendy; Turgut Karabağ | Zendy

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Acute Myocardial Infarction Caused by Filgrastim: A Case Report

Author(s) -

Cemil Bilir,

Hüseyin Engin,

Yasemin Bakkal Temi,

Bilal Toka,

Turgut Karabağ

Publication year - 2012

Publication title -

case reports in oncological medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.173

H-Index - 7

eISSN - 2090-6714

pISSN - 2090-6706

DOI - 10.1155/2012/784128

Subject(s) - medicine , filgrastim , myocardial infarction , chest pain , cardiology , lung cancer , st segment , depression (economics) , metastasis , chemotherapy , cancer , granulocyte colony stimulating factor , economics , macroeconomics

Common uses of the granulocyte-colony stimulating factors in the clinical practice raise the concern about side effects of these agents. We presented a case report about an acute myocardial infarction with non-ST segment elevation during filgrastim administration. A 73-year-old man had squamous cell carcinoma of larynx with lung metastasis treated with the chemotherapy. Second day after the filgrastim, patient had a chest discomfort. An ECG was performed and showed an ST segment depression and negative T waves on inferior derivations. A coronary angiography had showed a critical lesion in right coronary arteria. This is the first study thats revealed that G-CSF can cause acute myocardial infarction in cancer patients without history of cardiac disease. Patients with chest discomfort and pain who are on treatment with G-CSF or GM-CSF must alert the physicians for acute coronary events.

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